Principles of Clinical Pharmacology 3rd Edition by Shiew-Mei Huang

Principles of Clinical Pharmacology 3rd Edition by Shiew-Mei Huang | ISBN-13 9780123854711

Principles of Clinical Pharmacology is a successful survey covering the pharmacologic principles underlying the individualization of patient therapy and contemporary drug development. This essential reference continues to focus on the basics of clinical pharmacology for the development, evaluation, and clinical use of pharmaceutical products while also addressing the most recent advances in the field. Written by leading experts in academia, industry, clinical and regulatory settings, the third edition has been thoroughly updated to provide readers with an ideal reference covering the wide range of important topics impacting clinical pharmacology as the discipline plays an increasingly significant role in drug development and regulatory science.

The Third Edition has been endorsed by the American Society for Clinical Pharmacology and Therapeutics

Your Comprehensive Guide to Clinical Pharmacology

The Principles of Clinical Pharmacology, 3rd Edition, is an essential reference that delves into the pharmacological principles necessary for personalizing patient therapy and advancing drug development. This comprehensive guide covers the basics of clinical pharmacology while integrating cutting-edge developments in the field. Written by leading experts from academia, industry, clinical practice, and regulatory science, this authoritative text provides a foundational understanding of clinical pharmacology and its expanding role in drug development and regulatory practices.

Endorsed by the American Society for Clinical Pharmacology and Therapeutics, this third edition is a must-have resource for professionals and students in pharmacology, medicine, and pharmaceutical sciences.

Why Choose This Book?

1. Comprehensive Coverage: Spanning topics from pharmacokinetics and drug metabolism to drug discovery and regulatory science, the book addresses all facets of clinical pharmacology.
2. Up-to-Date Information: This edition incorporates the latest advancements in drug development, patient therapy individualization, and pharmacological research.
3. Expert Contributors: Authored by leading professionals, ensuring accuracy and relevance.
4. Practical and Theoretical Insights: Combines foundational principles with practical applications for clinical and regulatory settings.

Key Features

• Thoroughly Updated Content: Includes the latest insights on pharmacogenetics, disease progression models, and quality assessment of drug therapies.
• Comprehensive Structure: Organized into five parts covering pharmacokinetics, drug metabolism, drug effects, patient therapy optimization, and drug discovery and development.
• Study Aids: Features appendices with Laplace transforms and solutions to study problems for deeper understanding.
• Focus on Real-World Applications: Explains the role of the FDA, project management in drug development, and the design of clinical trials.

What You’ll Learn

Part 1: Pharmacokinetics

• Explore foundational principles of clinical pharmacokinetics.
• Understand compartmental and non-compartmental models of drug distribution.
• Learn the effects of renal and liver diseases on pharmacokinetics.
• Study population pharmacokinetics and distributed models of drug kinetics.

Part 2: Drug Metabolism and Transport

• Discover pathways of drug metabolism and mechanisms of drug toxicity.
• Examine drug interactions, chemical assays, and transport mechanisms.
• Gain insights into pharmacogenetics and its role in personalized medicine.

Part 3: Assessment of Drug Effects

• Understand physiological and laboratory markers of drug effects.
• Analyze dose-response relationships and kinetics of pharmacologic effects.
• Learn to model disease progression and its influence on therapy.

Part 4: Optimizing and Evaluating Patient Therapy

• Address sex differences in pharmacokinetics and pharmacodynamics.
• Explore drug therapy considerations for special populations, including pregnant women, neonates, and the elderly.
• Learn about adverse drug reaction analysis and quality assessment in drug therapy.

Part 5: Drug Discovery and Development

• Understand the drug development lifecycle, from discovery to clinical trials.
• Explore preclinical development, animal scaling, and phase I studies.
• Learn about pharmacokinetic and pharmacodynamic considerations for large molecules and biotechnology products.
• Gain practical insights into clinical trial design and regulatory guidance from the FDA.

Detailed Table of Contents

1. Introduction

Part 1: Pharmacokinetics

2. Clinical Pharmacokinetics
3. Compartmental Analysis of Drug Distribution
4. Drug Absorption and Bioavailability
5. Effects of Renal Disease on Pharmacokinetics
6. Kinetics of Hemodialysis and Hemofiltration
7. Effects of Liver Disease on Pharmacokinetics
8. Noncompartmental vs. Compartmental Approaches to Pharmacokinetic Analysis
9. Distributed Models of Drug Kinetics
10. Population Pharmacokinetics

Part 2: Drug Metabolism and Transport

11. Pathways of Drug Metabolism
12. Biochemical Mechanisms of Drug Toxicity
13. Chemical Assay of Drugs and Drug Metabolites
14. Equilibrative and Concentrative Transport
15. Pharmacogenetics
16. Drug Interactions

Part 3: Assessment of Drug Effects

17. Physiological and Laboratory Markers of Drug Effect
18. Dose-Response and Concentration-Response Analysis
19. Kinetics of Pharmacologic Effect
20. Disease Progression Models

Part 4: Optimizing and Evaluating Patient Therapy

21. Sex Differences in Pharmacokinetics and Pharmacodynamics
22. Drug Therapy in Pregnant and Nursing Women
23. Drug Therapy in Neonates and Pediatric Patients
24. Drug Therapy in the Elderly
25. Clinical Analysis of Adverse Drug Reactions
26. Quality Assessment of Drug Therapy

Part 5: Drug Discovery and Development

27. Project Management
28. Drug Discovery
29. Preclinical Development
30. Animal Scale-Up
31. Phase I Studies
32. PK and PD Considerations in the Development of Biotechnology Products and Large Molecules
33. Design of Clinical Development Programs
34. Good Design Practices for Clinical Trials
35. Role of the FDA in Guiding Drug Development

Who Should Read This Book?

• Students: A valuable learning resource for pharmacology, medical, and pharmaceutical science students.
• Healthcare Professionals: Enhance your understanding of personalized therapy and drug development.
• Pharmaceutical Scientists: A practical guide for navigating drug discovery, development, and regulatory requirements.
• Regulatory Professionals: Gain insights into the FDA’s role and best practices in clinical trial design.

Order Now

The Principles of Clinical Pharmacology, 3rd Edition, is your comprehensive reference for understanding the principles of pharmacology and its applications in drug development and patient therapy.

ISBN-13: 9780123854711
Don’t miss this essential resource—order your copy today to stay at the forefront of clinical pharmacology!